MDM2 promoter SNP344T>A (rs1196333) status does not affect cancer risk.

doi:10.1371/journal.pone.0036263

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Article

MDM2 promoter SNP344T>A (rs1196333) status does not affect cancer risk.

PloS one - 1 Jan 2012

Knappskog Stian, Gansmo Liv B, Romundstad Pål, Bjørnslett Merete, Trovik Jone, Sommerfelt-Pettersen Jan, Løkkevik Erik, Tollenaar Rob A E M, Seynaeve Caroline, Devilee Peter, Salvesen Helga B, Dørum Anne, Hveem Kristian, Vatten Lars, Lønning Per E

Abstract excerpt

The MDM2 proto-oncogene plays a key role in central cellular processes like growth control and apoptosis, and the gene locus is frequently amplified in sarcomas. Two polymorphisms located in the MDM2 promoter P2 have been shown to affect cancer risk. One of these polymorphisms (SNP309T>G; rs2279744) facilitates Sp1 transcription factor binding to the promoter and is associated with increased cancer risk. In...

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PMID: 22558411
DOI: 10.1371/journal.pone.0036263
PMCID: PMC3340411

Genes

MDM2
SPIB

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MDM2 promoter SNP344T>A (rs1196333) status does not affect cancer risk.PMID 22558411Read ↗

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MDM2 promoter SNP285 and SNP309; phylogeny and impact on cancer risk.Semantic proximity Read ↗

MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies.Semantic proximity Read ↗

MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer.Semantic proximity Read ↗

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Influence of MDM2 SNP309 and SNP285 status on the risk of cancer in the breast, prostate, lung and colon.Semantic proximity Read ↗

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SNP55, a new functional polymorphism of MDM2-P2 promoter, contributes to allele-specific expression of MDM2 in endometrial cancers.Semantic proximity Read ↗

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