Article
An HLA-C amino-acid variant in addition to HLA-B*27 confers risk for ankylosing spondylitis in the Korean population.
Arthritis research & therapy - 27 Nov 2015
Kim Kwangwoo, Bang So-Young, Lee Seunghun, Lee Hye-Soon, Shim Seung-Cheol, Kang Young Mo, Suh Chang-Hee, Sun Celi, Nath Swapan K, Bae Sang-Cheol, Kim Tae-Hwan
Abstract excerpt
INTRODUCTION: The presence of the HLA-B*27 allele is a major risk factor for the development of ankylosing spondylitis (AS), which causes chronic inflammation of the spine and other sites. We investigated residual effects outside HLA-B within the major histocompatibility complex (MHC) region in the Korean population. METHODS: Using the Korean HLA reference panel, we inferred the classic HLA alleles and amino-acid...
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