Article
Localization of PIP2 activation gate in inward rectifier K+ channels.
Nature neuroscience - 1 Aug 2003
Xiao Jun, Zhen Xiao-guang, Yang Jian
Abstract excerpt
Ion channels respond to changes in transmembrane voltage or ligand concentration by opening or closing an activation gate. In voltage-gated K+ channels, this gate has been localized to an intracellular bundle crossing. Here we examined whether this bundle crossing, or the more internal cytoplasmic pore, acts as a gate for PIP2 activation of inward rectifier K+ (Kir) channels expressed in Xenopus laevis oocytes....
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