Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway

19 Dec 2017

Abstract excerpt

ABSTRACT The type I interferon (IFN) system represents an essential innate immune response that renders cells resistant to virus growth via the molecular actions of IFN-induced effector proteins. IFN-mediated cellular states inhibit growth of numerous and diverse virus types, including those of known pathogenicity as well as potentially emerging agents. As such, targeted pharmacologic activation of the IFN...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to Mosquito-borne diseases and control
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29263267
DOI: 10.1128/jvi.01913-17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING PathwayPMID 29263267Read ↗

Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging AlphavirusesSemantic proximity Read ↗

Broad-spectrum antiviral inhibitors targeting pandemic potential RNA virusesSemantic proximity Read ↗

Alphaviruses: Host pathogenesis, immune response, and vaccine & treatment updatesSemantic proximity Read ↗

Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes AgonistSemantic proximity Read ↗

Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral ResponsesSemantic proximity Read ↗

Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infectionSemantic proximity Read ↗

JAK inhibitors remove innate immune barriers facilitating viral propagationSemantic proximity Read ↗

Interplay between RNA viruses and cGAS/STING axis in innate immunitySemantic proximity Read ↗

A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists.Semantic proximity Read ↗

Broad-spectrum RNA antiviral inspired by ISG15 <sup>-/-</sup> deficiencySemantic proximity Read ↗

Interferon alpha-based combinations suppress SARS-CoV-2 infection in vitro and in vivoSemantic proximity Read ↗

Identifying novel antiviral defences against VSV and HIV-1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.