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Article

Structure-mechanics relationships of collagen fibrils in the osteogenesis imperfecta mouse model.

Journal of the Royal Society, Interface - 6 Oct 2015

Andriotis O G, Chang S W, Vanleene M, Howarth P H, Davies D E, Shefelbine S J, Buehler M J, Thurner P J

Abstract excerpt

The collagen molecule, which is the building block of collagen fibrils, is a triple helix of two α1(I) chains and one α2(I) chain. However, in the severe mouse model of osteogenesis imperfecta (OIM), deletion of the COL1A2 gene results in the substitution of the α2(I) chain by one α1(I) chain. As this substitution severely impairs the structure and mechanics of collagen-rich tissues at the tissue and organ level,...

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Identifiers

PMID: 26468064
DOI: 10.1098/rsif.2015.0701
PMCID: PMC4614505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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