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Article

Single molecule effects of osteogenesis imperfecta mutations in tropocollagen protein domains.

Protein science : a publication of the Protein Society - 1 Jan 2009

Gautieri Alfonso, Vesentini Simone, Redaelli Alberto, Buehler Markus J

Abstract excerpt

Osteogenesis imperfecta (OI) is a genetic disease characterized by fragile bones, skeletal deformities and, in severe cases, prenatal death that affects more than 1 in 10,000 individuals. Here we show by full atomistic simulation in explicit solvent that OI mutations have a significant influence on the mechanical properties of single tropocollagen molecules, and that the severity of different forms of OI is...

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Identifiers

PMID: 19177360
DOI: 10.1002/pro.21
PMCID: PMC2708024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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