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Article

Knockout of p21-activated kinase-1 attenuates exercise-induced cardiac remodelling through altered calcineurin signalling.

Cardiovascular research - 1 Dec 2015

Davis Robert T, Simon Jillian N, Utter Megan, Mungai Paul, Alvarez Manuel G, Chowdhury Shamim A K, Heydemann Ahlke, Ke Yunbo, Wolska Beata M, Solaro R John

Abstract excerpt

AIMS: Despite its known cardiovascular benefits, the intracellular signalling mechanisms underlying physiological cardiac growth remain poorly understood. Therefore, the purpose of this study was to investigate a novel role of p21-activated kinase-1 (Pak1) in the regulation of exercise-induced cardiac hypertrophy. METHODS AND RESULTS: Wild-type (WT) and Pak1 KO mice were subjected to 6 weeks of treadmill...

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Identifiers

PMID: 26464331
DOI: 10.1093/cvr/cvv234
PMCID: PMC4648200

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