Article
Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress.
Nature medicine - 1 Dec 2004
Frey Norbert, Barrientos Tomasa, Shelton John M, Frank Derk, Rütten Hartmut, Gehring Doris, Kuhn Christian, Lutz Matthias, Rothermel Beverly, Bassel-Duby Rhonda, Richardson James A, Katus Hugo A, Hill Joseph A, Olson Eric N
Abstract excerpt
Signaling by the calcium-dependent phosphatase calcineurin profoundly influences the growth and gene expression of cardiac and skeletal muscle. Calcineurin binds to calsarcins, a family of muscle-specific proteins of the sarcomeric Z-disc, a focal point in the pathogenesis of human cardiomyopathies. We show that calsarcin-1 negatively modulates the functions of calcineurin, such that calcineurin signaling was...
Topics
- Adrenergic beta-Agonists
- Animals
- Biomechanical Phenomena
- Calcineurin
- Calcineurin Inhibitors
- Cardiomyopathies
- Carrier Proteins
- DNA Primers
- DNA-Binding Proteins