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Article

Metastasis-related genomic aberrations and evolutionary trajectory in uveal melanoma.

Experimental & molecular medicine - 1 Jun 2026

Nam Chang Hyun, Kim Yong Joon, Youk Jeonghwan, Park Hyo Song, Ju Young Seok, Lee Christopher Seungkyu

Abstract excerpt

Uveal melanoma (UM) is the most common primary intraocular cancer, characterized by genetic variations associated with metastasis-related mortality. Current prognostic classifications primarily rely on large-scale copy number alterations without incorporating more precise genomic aberrations. We present a comprehensive analysis of whole-genome sequences from 40 primary UMs and matched normal tissues, revealing a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42310376
DOI: 10.1038/s12276-026-01750-y
PMCID: PMC13324459

Genes

BAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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