Article
Genetic evolution of uveal melanoma guides the development of an inflammatory microenvironment.
Cancer immunology, immunotherapy : CII - 1 Jul 2017
Gezgin Gülçin, Dogrusöz Mehmet, van Essen T Huibertus, Kroes Wilhelmina G M, Luyten Gregorius P M, van der Velden Pieter A, Walter Vonn, Verdijk Robert M, van Hall Thorbald, van der Burg Sjoerd H, Jager Martine J
Abstract excerpt
Uveal melanoma (UM) is characterized by a number of genetic aberrations that follow a certain chronology and are tightly linked to tumor recurrence and survival. Loss of chromosome 3, bi-allelic loss of BAP1 expression, and gain in chromosome 8q have been associated with metastasis formation and death, while loss of chromosome 3 has been associated with the influx of macrophages and T cells. We used a set of...
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