Article
Genetic determinants of uveal melanoma.
Developments in ophthalmology - 1 Jan 2012
Couturier Jérôme, Saule Simon
Abstract excerpt
Uveal melanoma (UM) arises from neural crest-derived melanocytes of the choroid and the ciliary body. About 50% of patients develop metastatic disease despite efficient control of the primary tumor. For about 15 years, cytogenetic and, recently, genome-wide analysis techniques have shown that UM can be classified into 2 genomic groups correlating with prognostic clinicopathologic features: class 1 tumors, with a...
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