Article
Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases.
Proceedings of the National Academy of Sciences of the United States of America - 27 Oct 2015
Weeber Fleur, van de Wetering Marc, Hoogstraat Marlous, Dijkstra Krijn K, Krijgsman Oscar, Kuilman Thomas, Gadellaa-van Hooijdonk Christa G M, van der Velden Daphne L, Peeper Daniel S, Cuppen Edwin P J G, Vries Robert G, Clevers Hans, Voest Emile E
Abstract excerpt
Tumor organoids are 3D cultures of cancer cells. They can be derived from the tumor of each individual patient, thereby providing an attractive ex vivo assay to tailor treatment. Using patient-derived tumor organoids for this purpose requires that organoids derived from biopsies maintain the genetic diversity of the in vivo tumor. In this study tumor biopsies were obtained from 14 patients with metastatic...
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