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A simple bridging flocculation assay for rapid, sensitive and stringent detection of gene specific DNA methylation

13 Oct 2015

Abstract excerpt

The challenge of bringing DNA methylation biomarkers into clinic is the lack of simple methodologies as most current assays have been developed for research purposes. To address the limitations of current methods, we describe herein a novel methyl-protein domain (MBD) enrichment protocol for simple yet rapid and highly stringent selection of highly methylated DNA from limiting input samples. We then coupled this...

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PMID: 26458746
DOI: 10.1038/srep15028

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