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Article

Genetic variation affects congenital heart defect susceptibility in offspring exposed to maternal tobacco use.

Birth defects research. Part A, Clinical and molecular teratology - 1 Oct 2015

Tang Xinyu, Hobbs Charlotte A, Cleves Mario A, Erickson Stephen W, MacLeod Stewart L, Malik Sadia

Abstract excerpt

BACKGROUND: Congenital heart defects (CHDs) are among the most prevalent and serious birth defects, occurring in 8 to 10 of every 1000 live births in the United States. Epidemiologic studies have reported an association between CHDs and maternal smoking, but it remains unknown how genes impact the susceptibility of offspring to CHDs in the presence of maternal tobacco use. METHODS: Using data from 403 case- and...

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Source

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Identifiers

PMID: 26033827
DOI: 10.1002/bdra.23370
PMCID: PMC4774247

Genes

ERCC1
ERCC5
OSGEP
PARP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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