Assessment of interaction between maternal polycyclic aromatic hydrocarbons exposure and genetic polymorphisms on the risk of congenital heart diseases.

doi:10.1038/s41598-018-21380-3

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Article

Assessment of interaction between maternal polycyclic aromatic hydrocarbons exposure and genetic polymorphisms on the risk of congenital heart diseases.

Scientific reports - 15 Feb 2018

Li Nana, Mu Yi, Liu Zhen, Deng Ying, Guo Yixiong, Zhang Xuejuan, Li Xiaohong, Yu Ping, Wang Yanping, Zhu Jun

Abstract excerpt

The major causes of congenital heart diseases (CHDs) are the interactions of genetic and environmental factors. We conducted a case-control study in 357 mothers of CHDs fetuses and 270 control mothers to investigate the association of maternal PAHs exposure, AHR, CYP1A1, CYP1A2, CYP1B1 and CYP2E polymorphisms, the interaction between PAHs exposure and genetic variants with the risk of CHDs. The higher level PAHs...

Topics

Adult
Case-Control Studies
Cytochrome P-450 CYP1A1
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP1B1
Cytochrome P-450 CYP2E1
Cytochrome P-450 Enzyme System
Female
Fetus
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

Heart Defects, Congenital

Humans

Maternal Exposure

Polycyclic Aromatic Hydrocarbons

Polymorphism, Single Nucleotide

Pregnancy

Prenatal Exposure Delayed Effects

Source

Open in PubMed Open full text

Identifiers

PMID: 29449662
DOI: 10.1038/s41598-018-21380-3
PMCID: PMC5814464

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