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DNA damage response and cell fate decisions across the lifespan: from fetal development to age-related respiratory diseases

2 Aug 2025

Abstract excerpt

The integrity and stability of DNA, an essential genetic material, need to be maintained for normal cellular function, growth, and development. The DNA damage response (DDR) constitutes a complex, sophisticated, and extensive signaling network that preserves genomic stability under stress. It can be divided into the DNA damage surveillance system and DNA damage repair system, which work in concert to ensure...

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PMID: 40753255
DOI: 10.1186/s13578-025-01442-6

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