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Article

Insm1 controls the differentiation of pulmonary neuroendocrine cells by repressing Hes1.

Developmental biology - 1 Dec 2015

Jia Shiqi, Wildner Hendrik, Birchmeier Carmen

Abstract excerpt

Epithelial progenitor cells of the lung generate all cell types of the mature airway epithelium, among them the neuroendocrine cells. The balance between formation of pulmonary neuroendocrine and non-neuroendocrine cells is controlled by Notch signaling. The Notch target gene Hes1 is expressed by non-neuroendocrine and absent in neuroendocrine cells. The transcription factor Ascl1 is expressed in a complementary...

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PMID: 26453796
DOI: 10.1016/j.ydbio.2015.10.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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