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Article

Jagged1 is the major regulator of Notch-dependent cell fate in proximal airways.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2013

Zhang Shubing, Loch Amanda J, Radtke Freddy, Egan Sean E, Xu Keli

Abstract excerpt

BACKGROUND: The Notch signaling pathway plays complex roles in developing lungs, including regulation of proximodistal fates, airway cell specification and differentiation. However, the specific Notch-mediated signals involved in lung development remain unclear. RESULTS: Here we report that Jagged1 is expressed in a subset of bronchial and bronchiolar epithelial cells, where it controls proximal airway cell fate...

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Source

Identifiers

PMID: 23526493
DOI: 10.1002/dvdy.23965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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