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Article

Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain.

Development (Cambridge, England) - 1 Jul 2009

Jacob John, Storm Robert, Castro Diogo S, Milton Christopher, Pla Patrick, Guillemot François, Birchmeier Carmen, Briscoe James

Abstract excerpt

Monoaminergic neurons include the physiologically important central serotonergic and noradrenergic subtypes. Here, we identify the zinc-finger transcription factor, Insm1, as a crucial mediator of the differentiation of both subtypes, and in particular the acquisition of their neurotransmitter phenotype. Insm1 is expressed in hindbrain progenitors of monoaminergic neurons as they exit the cell cycle, in a pattern...

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Identifiers

PMID: 19542360
DOI: 10.1242/dev.034546
PMCID: PMC2729354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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