Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of the downstream targets of SIM1 and ARNT2, a pair of transcription factors essential for neuroendocrine cell differentiation.

The Journal of biological chemistry - 7 Nov 2003

Liu Chunqiao, Goshu Eleni, Wells Aynslee, Fan Chen-Ming

Abstract excerpt

SIM1 and ARNT2 are two basic helix-loop-helix/PAS (Per-Arnt-Sim) transcription factors that control the differentiation of neuroendocrine lineages in the mouse hypothalamus. Heterozygous Sim1 mice also develop early onset obesity, possibly due to hypodevelopment of the hypothalamus. Although SIM1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Receptor Nuclear Translocator
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dimerization

Share to Doxycycline

Share to Hypothalamus

Share to Janus Kinase 2

Share to Neurosecretory Systems

Share to Thyroid Hormone Receptors beta

Source

Identifiers

PMID: 12947113
DOI: 10.1074/jbc.M304489200

Genes

ARNT2
SIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12947113-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of the downstream targets of SIM1 and ARNT2, a pair of transcription factors essential for neuroendocrine cell differentiation.PMID 12947113Read ↗

Zebrafish diencephalic A11-related dopaminergic neurons share a conserved transcriptional network with neuroendocrine cell lineages.Semantic proximity Read ↗

Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamusSemantic proximity Read ↗

Functional characterization of SIM1-associated enhancers.Semantic proximity Read ↗

Profound obesity associated with a balanced translocation that disrupts the SIM1 gene.Semantic proximity Read ↗

Transcriptomic Profiling of Developing Melanocortin Neurons Reveals a Role for Prdm12 in Energy BalanceSemantic proximity Read ↗

Sim1 Haploinsufficiency Impairs Melanocortin-Mediated Anorexia and Activation of Paraventricular Nucleus NeuronsSemantic proximity Read ↗

Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.Semantic proximity Read ↗

A genomic atlas of mouse hypothalamic development.Semantic proximity Read ↗

Cumulative Effects of Genetic Variants Detected in a Child with Early-Onset Non-Syndromic Obesity Due to SIM-1 Gene MutationSemantic proximity Read ↗

Promoter or enhancer activation by CRISPRa rescues haploinsufficiency caused obesitySemantic proximity Read ↗

Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt.Semantic proximity Read ↗

<i>Mash1</i>Is Required for Generic and Subtype Differentiation of Hypothalamic Neuroendocrine CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.