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Article

Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons.

Cell - 5 Nov 1993

Guillemot F, Lo L C, Johnson J E, Auerbach A, Anderson D J, Joyner A L

Abstract excerpt

The mouse Mash-1 gene, like its Drosophila homologs of the achaete-scute complex (AS-C), encodes a transcription factor expressed in neural precursors. We created a null allele of this gene by homologous recombination in embryonic stem cells. Mice homozygous for the mutation die at birth with apparent breathing and feeding defects. The brain and spinal cord of the mutants appear normal, but their olfactory...

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PMID: 8221886
DOI: 10.1016/0092-8674(93)90381-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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