Article
Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons.
Cell - 5 Nov 1993
Guillemot F, Lo L C, Johnson J E, Auerbach A, Anderson D J, Joyner A L
Abstract excerpt
The mouse Mash-1 gene, like its Drosophila homologs of the achaete-scute complex (AS-C), encodes a transcription factor expressed in neural precursors. We created a null allele of this gene by homologous recombination in embryonic stem cells. Mice homozygous for the mutation die at birth with app...
Topics
- Adrenal Medulla
- Animals
- Animals, Newborn
- Autonomic Nervous System
- Base Sequence
- Basic Helix-Loop-Helix Transcription Factors
- Chromaffin System
- DNA-Binding Proteins
- Epithelium
- Ganglia
- Genes, Lethal
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutagenesis
- Neural Crest
- Neuroglia
- Neurons, Afferent