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Article

Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer

30 Sept 2015

Abstract excerpt

CDK8 and its paralog CDK19, in complex with CCNC, MED12 and MED13, are transcriptional regulators that mediate several carcinogenic pathways and the chemotherapy-induced tumor-supporting paracrine network. Following up on our previous observation that CDK8, CDK19 and CCNC RNA expression is associated with shorter relapse-free survival (RFS) in breast cancer, we now found by immunohistochemical analysis that...

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PMID: 26452386
DOI: 10.2174/156800961508151001105814

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