Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional characterization of the 19q12 amplicon in grade III breast cancers

20 Mar 2012

Abstract excerpt

INTRODUCTION: The 19q12 locus is amplified in a subgroup of oestrogen receptor (ER)-negative grade III breast cancers. This amplicon comprises nine genes, including cyclin E1 (CCNE1), which has been proposed as its 'driver'. The aim of this study was to identify the genes within the 19q12 amplicon whose expression is required for the survival of cancer cells harbouring their amplification. METHODS: We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Cancer Treatment Studies
Share to Cancer-related Molecular Pathways
Share to Genomic variations and chromosomal abnormalities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22433433
DOI: 10.1186/bcr3154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional characterization of the 19q12 amplicon in grade III breast cancersPMID 22433433Read ↗

Amplicon-Dependent CCNE1 Expression Is Critical for Clonogenic Survival after Cisplatin Treatment and Is Correlated with 20q11 Gain in Ovarian CancerSemantic proximity Read ↗

CDK19 is a Regulator of Triple-Negative Breast Cancer GrowthSemantic proximity Read ↗

Identifying Cancers Impacted by CDK8/19Semantic proximity Read ↗

Focal aberrations indicate <i>EYA2</i> and <i>hsa‐miR‐375</i> as oncogene and tumor suppressor in cervical carcinogenesisSemantic proximity Read ↗

A distinctive ovarian cancer molecular subgroup characterized by poor prognosis and somatic focal copy number amplifications at chromosome 19.Semantic proximity Read ↗

LncRNA RP11-19E11 is an E2F1 target required for proliferation and survival of basal breast cancerSemantic proximity Read ↗

Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast CancerSemantic proximity Read ↗

Translocation-driven chr19-der(14) interaction is associated with disease-specific transcriptional programs in mantle cell lymphomaSemantic proximity Read ↗

19q12 amplified and non-amplified subsets of high grade serous ovarian cancer with overexpression of cyclin E1 differ in their molecular drivers and clinical outcomesSemantic proximity Read ↗

Evolution of chromosome arm aberrations in breast cancer through genetic network rewiringSemantic proximity Read ↗

<i>STK11</i> mutations and deletions define a distinct subtype of cervical adenocarcinomaSemantic proximity Read ↗

Molecular cytogenetic identification of subgroups of grade III invasive ductal breast carcinomas with different clinical outcomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.