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Gonadotropin Signaling in Zebrafish Ovary and Testis Development: Insights From Gene Knockout Study

9 Oct 2015

Abstract excerpt

Using the transcription activator-like effectors nucleases-mediated gene knockout technology, we have previously demonstrated that LH signaling is required for oocyte maturation and ovulation but is dispensable for testis development in zebrafish. Here, we have further established the fshb and fshr knockout zebrafish lines. In females, fshb mutant is subfertile, whereas fshr mutant is infertile. Folliculogenesis...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 26452104
DOI: 10.1210/me.2015-1126

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