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Gene knockout analysis reveals essentiality of estrogen receptor β1 (Esr2a) for female reproduction in medaka

20 Jun 2019

Abstract excerpt

Abstract In vertebrates, sex steroids play crucial roles in multiple systems related to reproduction. In females, estrogens and their receptor estrogen receptor (ER or Esr) play indispensable roles in the negative sex steroid feedback regulation of pituitary gonadotropin secretion, which prevents excessive development of ovarian follicles. However, the mechanism of this feedback regulation of a gonadotropin,...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Hypothalamic control of reproductive hormones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Reproductive biology and impacts on aquatic species

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PMID: 31222039
DOI: 10.1038/s41598-019-45373-y

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