Genetic evidence for Amh modulation of gonadotropin actions to control gonadal homeostasis and gametogenesis in zebrafish and its noncanonical signalling through Bmpr2a receptor

Abstract excerpt

Anti-Müllerian hormone (AMH/Amh) plays an important role in gonadal function. Amh deficiency caused severe gonadal dysgenesis and dysfunction in zebrafish with gonadal hypertrophy in both sexes. However, its action mechanism remains unknown. Intriguingly, the Amh cognate type II receptor (Amhr2) is missing in the zebrafish genome, in sharp contrast to other species. Using a series of zebrafish mutants (amh, fshb,...

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