The highly overlapping actions of Lh signaling and Fsh signaling on zebrafish spermatogenesis

Abstract excerpt

Gonadotropin signaling plays a pivotal role in the spermatogenesis of vertebrates, but exactly how gonadotropins regulate the process in non-mammalian species remains elusive. Using a gene knockout approach in zebrafish, we have previously demonstrated the non-canonical action of gonadotropin signaling on spermatogenesis by analyzing four single mutant lines ( lhb , lhr , fshb and fshr ) and three double mutant...

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