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Article

Liquid biopsy-based tumor profiling for metastatic colorectal cancer patients with ultra-deep targeted sequencing.

PloS one - 1 Jan 2020

Kang Jun-Kyu, Heo Sunghoon, Kim Hwang-Phill, Song Sang-Hyun, Yun Hongseok, Han Sae-Won, Kang Gyeong Hoon, Bang Duhee, Kim Tae-You

Abstract excerpt

Analyzing cell-free DNA (cfDNA) as a source of circulating tumor DNA is useful for diagnosing or monitoring patients with cancer. However, the concordance between cfDNA within liquid biopsy and genomic DNA (gDNA) within tumor tissue biopsy is still under debate. To evaluate the concordance in a clinical setting, we enrolled 54 patients with metastatic colorectal cancer and analyzed their plasma cfDNA, gDNA from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32379795
DOI: 10.1371/journal.pone.0232754
PMCID: PMC7205246

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