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Article

A New Epigenetic Mechanism of Temozolomide Action in Glioma Cells

26 Aug 2015

Abstract excerpt

Temozolomide (TMZ) is an oral alkylating chemotherapeutic agent that prolongs the survival of patients with glioblastoma (GBM). Despite that high TMZ potential, progression of disease and recurrence are still observed. Therefore a better understanding of the mechanism of action of this drug is necessary and may allow more durable benefit from its anti-glioma properties. Using nucleotide post-labelling method and...

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PMID: 26309255
DOI: 10.1371/journal.pone.0136669

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