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Fetal Val108/158Met catechol-O-methyltransferase (COMT) polymorphism and placental COMT activity are associated with the development of preeclampsia.

Fertility and sterility - 1 Jan 2016

Pertegal Miriam, Fenoy Francisco J, Hernández Moisés, Mendiola Jaime, Delgado Juan L, Bonacasa Bárbara, Corno Andrés, López Bernardo, Bosch Vicente, Hernández Isabel

Abstract excerpt

OBJECTIVE: To evaluate the association between fetal and maternal catechol-O-methyltransferase (COMT) Val158Met and methyl tetrahydrofolate reductase (MTHFR) C677T functional polymorphisms and preeclampsia, examining its influence on placental COMT and in maternal 2-methoxyestradiol (2-ME) plasma levels. DESIGN: Prospective case-control study. SETTING: University hospital. PATIENT(S): A total of 53 preeclamptic...

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Identifiers

PMID: 26450530
DOI: 10.1016/j.fertnstert.2015.09.019

Genes

COMT
MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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