Article
A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2).
Molecular human reproduction - 1 Jul 2011
Roten L T, Fenstad M H, Forsmo S, Johnson M P, Moses E K, Austgulen R, Skorpen F
Abstract excerpt
The etiology of preeclampsia is complex, with susceptibility being attributable to multiple environmental factors and a large genetic component. Although many candidate genes for preeclampsia have been suggested and studied, the specific causative genes still remain to be identified. Catechol-O-methyltransferase (COMT) is an enzyme involved in catecholamine and estrogen degradation and has recently been ascribed...
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