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Article

Low 2-methoxyestradiol levels at the first trimester of pregnancy are associated with the development of pre-eclampsia.

Prenatal diagnosis - 1 Nov 2012

Pérez-Sepúlveda Alejandra, Torres María José, Valenzuela Francisco J, Larraín Raimundo, Figueroa-Diesel Horacio, Galaz José, Nien Jyh Kae, Serra Ramón, Michea Luis, Illanes Sebastián E

Abstract excerpt

OBJECTIVE: To determine whether maternal plasma levels of 2-methoxyestradiol (2-ME) are decreased early in pregnancies that subsequently develop pre-eclampsia (PE) and whether this difference could be attributed to the presence of Val158Met catechol-O-methyltransferase (COMT) polymorphism in the placenta. METHODS: Clinical characteristics and plasma samples were collected at 11 to 14 weeks prospectively in a...

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Source

Identifiers

PMID: 22886584
DOI: 10.1002/pd.3954

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Low 2-methoxyestradiol levels at the first trimester of pregnancy are associated with the development of pre-eclampsia.PMID 22886584Read ↗

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