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Article

VAL158MET catechol O-methyltransferase polymorphism contributes to the development of preeclampsia.

Hypertension in pregnancy - 1 Nov 2020

Sljivancanin Jakovljevic Tamara, Kontic-Vucinic Olivera, Nikolic Nadja, Carkic Jelena, Milasin Jelena

Abstract excerpt

Objectives: Establishment of association between: (a) Val158Met COMT (G1947A) polymorphism and preeclampsia; (b) cytokines gene expression and COMT genotypes. Methods: 50 preeclampsia and 50 healthy pregnant women were enrolled. COMT genotyping was done by PCR/RFLP. TNF-α, IL-1β, and IL-6 mRNA levels were determined by Real-time PCR. Results: Variant (AA) homozygotes carried 3.7-fold increased preeclampsia odds,...

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Source

Identifiers

PMID: 33155880
DOI: 10.1080/10641955.2020.1843663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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