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Article

Conserved aromatic residue confers cation selectivity in claudin-2 and claudin-10b.

The Journal of biological chemistry - 2 Aug 2013

Li Jiahua, Zhuo Min, Pei Lei, Yu Alan S L

Abstract excerpt

In tight junctions, both claudin-2 and claudin-10b form paracellular cation-selective pores by the interaction of the first ECL 1 with permeating ions. We hypothesized that a highly conserved aromatic residue near the pore selectivity filter of claudins contributes to cation selectivity by cation-π interaction with the permeating cation. To test this, we generated MDCK I Tet-off cells stably transfected with...

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PMID: 23760508
DOI: 10.1074/jbc.M113.484238
PMCID: PMC3829363

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