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Article

Evaluation of a Yersinia pestis mutant impaired in a thermoregulated type VI-like secretion system in flea, macrophage and murine models.

Microbial pathogenesis - 1 Nov 2009

Robinson Jennilee B, Telepnev Maxim V, Zudina Irina V, Bouyer Donald, Montenieri John A, Bearden Scott W, Gage Kenneth L, Agar Stacy L, Foltz Sheri M, Chauhan Sadhana, Chopra Ashok K, Motin Vladimir L

Abstract excerpt

Type VI secretion systems (T6SSs) have been identified recently in several Gram-negative organisms and have been shown to be associated with virulence in some bacterial pathogens. A T6SS of Yersinia pestis CO92 (locus YPO0499-YPO0516) was deleted followed by investigation of the phenotype of this mutation. We observed that this T6SS locus of Y. pestis was preferentially expressed at 26 degrees C in comparison to...

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Identifiers

PMID: 19716410
DOI: 10.1016/j.micpath.2009.08.005
PMCID: PMC2767420

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