Article
A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics.
Cancer discovery - 1 Dec 2015
Sadanandam Anguraj, Wullschleger Stephan, Lyssiotis Costas A, Grötzinger Carsten, Barbi Stefano, Bersani Samantha, Körner Jan, Wafy Ismael, Mafficini Andrea, Lawlor Rita T, Simbolo Michele, Asara John M, Bläker Hendrik, Cantley Lewis C, Wiedenmann Bertram, Scarpa Aldo, Hanahan Douglas
Abstract excerpt
UNLABELLED: Seeking to assess the representative and instructive value of an engineered mouse model of pancreatic neuroendocrine tumors (PanNET) for its cognate human cancer, we profiled and compared mRNA and miRNA transcriptomes of tumors from both. Mouse PanNET tumors could be classified into two distinctive subtypes, well-differentiated islet/insulinoma tumors (IT) and poorly differentiated tumors associated...
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