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Article

Molecular and Functional Heterogeneity of Primary Pancreatic Neuroendocrine Tumors and Metastases.

Neuroendocrinology - 1 Jan 2023

Guo Yiying, Tian Chao, Cheng Zixuan, Chen Ruao, Li Yuanliang, Su Fei, Shi Yanfen, Tan Huangying

Abstract excerpt

INTRODUCTION: Treatment response to the standard therapy is low for metastatic pancreatic neuroendocrine tumors (PanNETs) mainly due to the tumor heterogeneity. We investigated the heterogeneity between primary PanNETs and metastases to improve the precise treatment. METHODS: The genomic and transcriptomic data of PanNETs were retrieved from the Genomics, Evidence, Neoplasia, Information, Exchange (GENIE), and...

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Mutation
Neuroendocrine Tumors
Pancreatic Neoplasms
Proto-Oncogene Proteins p21(ras)
Signal Transduction

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PMID: 37232011
DOI: 10.1159/000530968
PMCID: PMC10614458

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