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AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes

1 Jan 2015

Abstract excerpt

Adeno-associated virus (AAV) has become one of the most promising vectors in gene transfer in the last 10 years with successful translation to clinical trials in humans and even market approval for a first gene therapy product in Europe. Administration to humans, however, revealed that adaptive immune responses against the vector capsid can present an obstacle to sustained transgene expression due to the...

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PMID: 26445723
DOI: 10.1038/mtm.2015.29

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