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Article

Exposure to wild-type AAV drives distinct capsid immunity profiles in humans

22 Oct 2018

Abstract excerpt

Recombinant adeno-associated virus (AAV) vectors have been broadly adopted as a gene delivery tool in clinical trials, owing to their high efficiency of transduction of several host tissues and their low immunogenicity. However, a considerable proportion of the population is naturally exposed to the WT virus from which AAV vectors are derived, which leads to the acquisition of immunological memory that can...

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Share to Herpesvirus Infections and Treatments
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30352429
DOI: 10.1172/jci122372

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