Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Humoral and Cellular Capsid-Specific Immune Responses to Adeno-Associated Virus Type 1 in Randomized Healthy Donors

17 May 2012

Abstract excerpt

A major impediment to the use of adeno-associated virus (AAV)-mediated gene delivery to muscle in clinical applications is the pre-existing immune responses against the vector. Pre-existing humoral response to different AAV serotypes is now well documented. In contrast, cellular responses to AAV capsid have not been analyzed in a systematic manner, despite the risk of T cell reactivation upon gene transfer. AAV1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Viral Infectious Diseases and Gene Expression in Insects
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22593612
DOI: 10.4049/jimmunol.1200620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Humoral and Cellular Capsid-Specific Immune Responses to Adeno-Associated Virus Type 1 in Randomized Healthy DonorsPMID 22593612Read ↗

Unraveling the Complex Story of Immune Responses to AAV Vectors Trial After TrialSemantic proximity Read ↗

Prevalence study of cellular capsid-specific immune responses to AAV2, 4, 5, 8, 9 and rh10 in healthy donorsSemantic proximity Read ↗

Prevalence Study of Cellular Capsid-Specific Immune Responses to AAV2, 4, 5, 8, 9, and rh10 in Healthy DonorsSemantic proximity Read ↗

Exposure to wild-type AAV drives distinct capsid immunity profiles in humansSemantic proximity Read ↗

AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypesSemantic proximity Read ↗

Cell-Mediated Immunity to AAV Vectors, Evolving Concepts and Potential SolutionsSemantic proximity Read ↗

Impact of AAV Capsid-Specific T-Cell Responses on Design and Outcome of Clinical Gene Transfer Trials with Recombinant Adeno-Associated Viral Vectors: An Evolving ControversySemantic proximity Read ↗

Human Immune Responses to Adeno-Associated Virus (AAV) VectorsSemantic proximity Read ↗

Adeno-associated virus serotype 2 induces cell-mediated immune responses directed against multiple epitopes of the capsid protein VP1.Semantic proximity Read ↗

Immunity and AAV-Mediated Gene Therapy for Muscular Dystrophies in Large Animal Models and Human TrialsSemantic proximity Read ↗

Assessment of Humoral, Innate, and T-Cell Immune Responses to Adeno-Associated Virus VectorsSemantic proximity Read ↗

Immune Responses to AAV in Clinical TrialsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.