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Article

The HLA class I immunopeptidomes of AAV capsid proteins.

Frontiers in immunology - 1 Jan 2023

Brito-Sierra Carlos A, Lannan Megan B, Malherbe Laurent P, Siegel Robert W

Abstract excerpt

Introduction: Cellular immune responses against AAV vector capsid represent an obstacle for successful gene therapy. Previous studies have used overlapping peptides spanning the entire capsid sequence to identify T cell epitopes recognized by AAV-specific CD8+ T cells. However, the repertoire of peptides naturally displayed by HLA class I molecules for CD8 T cell recognition is unknown. Methods: Using mRNA...

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Alleles
Capsid
Capsid Proteins
Epitopes, T-Lymphocyte
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37662941
DOI: 10.3389/fimmu.2023.1212136
PMCID: PMC10469481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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