Article

Prevalence study of cellular capsid-specific immune responses to AAV2, 4, 5, 8, 9 and rh10 in healthy donors

2023-12-21

Abstract excerpt

<h4>ABSTRACT</h4> Recombinant adeno-associated virus (rAAV) vectors appear, more than ever, to be efficient viral vectors for in vivo gene transfer as illustrated by the approvals of 7 drugs across Europe and the USA. Nevertheless, pre-existing immunity to AAV capsid in humans remains one of the major limits for a successful clinical translation. Whereas pre-existing humoral response to AAV capsid is well docume...

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Literature Corpus work: cb51e30a-3cc4-51c0-b543-57617fdd68db
DOI: 10.1101/2023.12.20.570598

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