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Article

Amnion signals are essential for mesoderm formation in primates

2020-05-28

Abstract excerpt

Essential genes for murine embryonic development can demonstrate a disparate phenotype in human cohorts. By generating a transcriptional atlas containing >30,000 cells from postimplantation non-human primate embryos, we discovered that ISL1 , a gene with a well-established role in cardiogenesis, controls a gene regulatory network in primate amnion. CRISPR/Cas9-targeting of ISL1 resulted in non-human primate embr...

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Identifiers and source

Literature Corpus work
d2840887-78b6-51dd-bf91-97c04fbd24a8
DOI
10.1101/2020.05.28.118703
Open publication

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Amnion signals are essential for mesoderm formation in primatesDOI 10.1101/2020.05.28.118703
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