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Article

Factors governing loss and rescue of DNA binding upon single and double mutations in the p53 core domain.

Nucleic acids research - 1 Apr 2002

Wright Jon D, Noskov Sergey Yu, Lim Carmay

Abstract excerpt

The mutation of R273-->H in the p53 core domain (p53-CD) is one of the most common mutations found in human cancers. Although the 273H p53-CD retains the wild-type conformation and stability, it lacks sequence-specific DNA binding, a transactivation function and growth suppression. However, mutat...

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Identifiers

PMID: 11917017
DOI: 10.1093/nar/30.7.1563
PMCID: PMC101848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11917017-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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