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Article

Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations.

The EMBO journal - 1 Feb 2000

Nikolova P V, Wong K B, DeDecker B, Henckel J, Fersht A R

Abstract excerpt

The core domain of p53 is extremely susceptible to mutations that lead to loss of function. We analysed the stability and DNA-binding activity of such mutants to understand the mechanism of second-site suppressor mutations. Double-mutant cycles show that N239Y and N268D act as 'global stability' suppressors by increasing the stability of the cancer mutants G245S and V143A-the free energy changes are additive....

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Share to Intracellular Signaling Peptides and Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10654936
DOI: 10.1093/emboj/19.3.370
PMCID: PMC305574

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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