Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.

doi:10.1002/art.27457

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Article

Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.

Arthritis and rheumatism - 1 Jul 2010

Cui Jing, Saevarsdottir Saedis, Thomson Brian, Padyukov Leonid, van der Helm-van Mil Annette H M, Nititham Joanne, Hughes Laura B, de Vries Niek, Raychaudhuri Soumya, Alfredsson Lars, Askling Johan, Wedrén Sara, Ding Bo, Guiducci Candace, Wolbink Gert Jan, Crusius J Bart A, van der Horst-Bruinsma Irene E, Herenius Marieke, Weinblatt Michael E, Shadick Nancy A, Worthington Jane, Batliwalla Franak, Kern Marlena, Morgan Ann W, Wilson Anthony G, Isaacs John D, Hyrich Kimme, Seldin Michael F, Moreland Larry W, Behrens Timothy W, Allaart Cornelia F, Criswell Lindsey A, Huizinga Tom W J, Tak Paul P, Bridges S Louis, Toes Rene E M, Barton Anne, Klareskog Lars, Gregersen Peter K, Karlson Elizabeth W, Plenge Robert M

Abstract excerpt

OBJECTIVE: Anti-tumor necrosis factor alpha (anti-TNF) therapy is a mainstay of treatment in rheumatoid arthritis (RA). The aim of the present study was to test established RA genetic risk factors to determine whether the same alleles also influence the response to anti-TNF therapy. METHODS: A total of 1,283 RA patients receiving etanercept, infliximab, or adalimumab therapy were studied from among an...

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Identifiers

PMID: 20309874
DOI: 10.1002/art.27457
PMCID: PMC3652476

Genes

PTPRC
TNF

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