The burden of multiple sclerosis variants in continental Italians and Sardinians.

doi:10.1177/1352458515596599

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Article

The burden of multiple sclerosis variants in continental Italians and Sardinians.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Oct 2015

Barizzone Nadia, Zara Ilenia, Sorosina Melissa, Lupoli Sara, Porcu Eleonora, Pitzalis Maristella, Zoledziewska Magdalena, Esposito Federica, Leone Maurizio, Mulas Antonella, Cocco Eleonora, Ferrigno Paola, Guerini Franca R, Brambilla Paola, Farina Gabriele, Murru Raffaele, Deidda Francesca, Sanna Sonia, Loi Alessia, Barlassina Cristina, Vecchio Domizia, Zauli Andrea, Clarelli Ferdinando, Braga Daniele, Poddie Fausto, Cantello Roberto, Martinelli Vittorio, Comi Giancarlo, Frau Jessica, Lorefice Lorena, Pugliatti Maura, Rosati Giulio, Melis Maurizio, Marrosu Maria G, Cusi Daniele, Cucca Francesco, Martinelli Boneschi Filippo, Sanna Serena, D'Alfonso Sandra

Abstract excerpt

BACKGROUND: Recent studies identified > 100 non-HLA (human leukocyte antigen) multiple sclerosis (MS) susceptibility variants in Northern European populations, but their role in Southern Europeans is largely unexplored. OBJECTIVE: We aimed to investigate the cumulative impact of those variants in two Mediterranean populations: Continental Italians and Sardinians. METHODS: We calculated four weighted Genetic Risk...

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PMID: 26438306
DOI: 10.1177/1352458515596599

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