Article
Investigating multiple sclerosis genetic susceptibility on the founder population of east-central Sardinia via association and linkage analysis of immune-related loci.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Dec 2018
Fazia Teresa, Pastorino Roberta, Foco Luisa, Han Lide, Abney Mark, Beecham Ashley, Hadjixenofontos Athena, Guo Hui, Gentilini Davide, Papachristou Charalampos, Bitti Pier Paolo, Ticca Anna, Berzuini Carlo, McCauley Jacob L, Bernardinelli Luisa
Abstract excerpt
BACKGROUND: A wealth of single-nucleotide polymorphisms (SNPs) responsible for multiple sclerosis (MS) susceptibility have been identified; however, they explain only a fraction of MS heritability. OBJECTIVES: We contributed to discovery of new MS susceptibility SNPs by studying a founder population with high MS prevalence. METHODS: We analyzed ImmunoChip data from 15 multiplex families and 94 unrelated controls...
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