Article
T-regulatory cells in primary immune deficiencies.
Current opinion in allergy and clinical immunology - 1 Dec 2011
Verbsky James W, Chatila Talal A
Abstract excerpt
PURPOSE OF REVIEW: To summarize studies on the development and function of T-regulatory (TR) cells in primary immune deficiencies (PIDs). RECENT FINDINGS: PIDs are associated with high rates of autoimmunity. TR cells, which are critical to the control of autoimmunity, appear involved in the pathogenesis of PID-related autoimmunity. A number of PIDs, including Omenn's syndrome and Wiskott-Aldrich syndrome, have...
Topics
- Animals
- Autoimmunity
- Humans
- Immunologic Deficiency Syndromes
- Membrane Proteins
- Mutation
- Neoplasm Proteins
- Peripheral Tolerance
- Receptors, Interleukin-10
- Stromal Interaction Molecule 1
- T-Lymphocyte Subsets