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Article

Integrin α5 and Integrin α4 cooperate to promote endocardial differentiation and heart morphogenesis.

Developmental biology - 1 Sept 2020

Schumacher Jennifer A, Wright Zoë A, Owen Mackenzie L, Bredemeier Nina O, Sumanas Saulius

Abstract excerpt

Endocardium is critically important for proper function of the cardiovascular system. Not only does endocardium connect the heart to blood vasculature, it also plays an important role in heart morphogenesis, valve formation, and ventricular trabeculation. The extracellular protein Fibronectin (Fn1) promotes endocardial differentiation, but the signaling pathways downstream of Fn1 that regulate endocardial...

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Identifiers

PMID: 32628938
DOI: 10.1016/j.ydbio.2020.06.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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